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[控制小鼠体内抑制巨噬细胞向白色念珠菌抗原和结核菌素迁移的一种因子产量的基因的表型表达]

[The phenotypic expression of the genes controlling the yield of a factor suppressing macrophage migration to Candida albicans antigens and tuberculin in mice].

作者信息

Vorob'ev K V, Gankovskaia L V, Koval'chuk L V, Vasil'ev O D

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1990 Oct(10):109-12.

PMID:2150140
Abstract

The regulation of the synthesis of factor inhibiting the migration of macrophages in response to C. albicans antigen in CBA (H-2k) and C57BL/6 (H-2b) mice has been studied. The low level of macrophage migration inhibition factor in response to this antigen is due to the existence of cyclophosphamide-inhibited specific suppressors. Differences between various strains of mice ensue from different activity of suppressors of thymic origin, whose nature has been revealed as the result of the transfer of marrow cells treated with anti-Thy-1 serum.

摘要

已对CBA(H-2k)和C57BL/6(H-2b)小鼠中,针对白色念珠菌抗原的巨噬细胞迁移抑制因子合成的调节进行了研究。对该抗原的巨噬细胞迁移抑制因子水平较低是由于存在环磷酰胺抑制的特异性抑制因子。不同品系小鼠之间的差异源于胸腺来源抑制因子的不同活性,通过用抗Thy-1血清处理的骨髓细胞转移,揭示了其性质。

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