Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Netherlands.
Pediatrics. 2011 May;127(5):e1169-75. doi: 10.1542/peds.2010-1147. Epub 2011 Apr 18.
To determine nationwide general practitioner (GP)-diagnosed prevalence and pediatrician-diagnosed incidence rates of adolescent chronic fatigue syndrome (CFS), and to assess CFS morbidity.
We collected data from a cross-sectional national sample among GPs and prospective registration of new patients with CFS in all pediatric hospital departments in the Netherlands.
Study participants were adolescents aged 10 to 18 years. A representative sample of GPs completed questionnaires on the prevalence of CFS in their adolescent patients. Pediatric hospital departments prospectively reported new cases of CFS in adolescent patients. For every new reported case, a questionnaire was sent to the reporting pediatrician and the reported patient to assess CFS morbidity. Prevalence was estimated through the data from GP questionnaires and incidence was estimated on the basis of cases newly reported by pediatricians from January to December 2008.
Prevalence was calculated as 111 per 100 000 adolescents and incidence as 12 per 100 000 adolescents per year. Of newly reported patients with CFS, 91% scored at or above cutoff points for severe fatigue and 93% at or above the cutoff points for physical impairment. Forty-five percent of patients with CFS reported >50% school absence during the previous 6 months.
Clinically diagnosed incidence and prevalence rates show that adolescent CFS is uncommon compared with chronic fatigue. The primary adverse impact of CFS is extreme disability associated with considerable school absence.
确定全国范围内全科医生（GP）诊断的青少年慢性疲劳综合征（CFS）患病率和儿科医生诊断的发病率，并评估 CFS 的发病情况。
我们从荷兰全国范围内的 GP 横断面抽样数据和所有儿科医院科室新诊断的 CFS 患者前瞻性登记中收集数据。
研究参与者为 10 至 18 岁的青少年。具有代表性的 GP 样本完成了关于其青少年患者 CFS 患病率的调查问卷。儿科医院科室前瞻性报告青少年患者新诊断的 CFS 病例。对于每例新报告的病例，都会向报告的儿科医生和报告的患者发送一份问卷，以评估 CFS 的发病情况。患病率是通过 GP 问卷的数据估计的，发病率是根据 2008 年 1 月至 12 月儿科医生新报告的病例估计的。
患病率计算为每 100000 名青少年中有 111 例，发病率计算为每 100000 名青少年每年有 12 例。新报告的 CFS 患者中，91%的患者达到或超过严重疲劳的临界值，93%的患者达到或超过身体损伤的临界值。45%的 CFS 患者报告在过去 6 个月中有超过 50%的缺课。
临床诊断的发病率和患病率表明，与慢性疲劳相比，青少年 CFS 并不常见。CFS 的主要不良影响是与严重缺课相关的极度残疾。
