Gendrel D, Roger M, Chaussain J L, Canlorbe P, Job J C
Acta Endocrinol (Copenh). 1977 Nov;86(3):641-50. doi: 10.1530/acta.0.0860641.
LH-RH test and HCG stimulation test were performed in 154 cryptorchid boys aged 1 month to 15 years (64 unilateral and 90 bilateral). Basal plasma LH levels and LH response to LH-RH were significantly lower from infancy to early puberty in cryptorchids compared with controls. Basal FSH levels and FSH response to LH-RH were normal. The post-HCG rise of plasma testosterone was reduced until mid-puberty. A significant positive correlation was found between post-HCG testosterone levels and pre- and post-LH-RH levels of LH. This correlation suggests that testicular maldescent and the decreased ability of Leydig cells to respond to a short course of HCG may result from an early defect or a delay of pituitary LH secretion.
对154名年龄在1个月至15岁的隐睾男孩（64名单侧隐睾和90名双侧隐睾）进行了促黄体生成素释放激素（LH-RH）试验和人绒毛膜促性腺激素（HCG）刺激试验。与对照组相比，隐睾患儿从婴儿期到青春期早期的基础血浆促黄体生成素（LH）水平以及LH对LH-RH的反应均显著降低。基础促卵泡生成素（FSH）水平以及FSH对LH-RH的反应正常。直到青春期中期，HCG刺激后血浆睾酮的升高仍降低。HCG刺激后的睾酮水平与LH-RH刺激前后的LH水平之间存在显著正相关。这种相关性表明，睾丸下降异常以及睾丸间质细胞对短期HCG刺激反应能力下降可能是由于垂体LH分泌的早期缺陷或延迟所致。
