Cacciari E, Cicognani A, Pirazzoli P, Zappulla F, Tassoni P, Bernardi F, Salardi S, Mazzanti L
Acta Paediatr Scand. 1977 May;66(3):345-8. doi: 10.1111/j.1651-2227.1977.tb07905.x.
In 22 normal and 35 obese boys a gonadal function test (2000 IU of hCG i.m. daily for three days and assays of plasma testosterone before and after the hCG administration) was carried out. All the "short normal" children and 31 obese subjects underwent the LH-RH test (50 microng i.v.). While basal testosterone was similar in the two groups of children, after hCG testosterone was significantly (p less than 0.001) lower in the obese boys, In the normal children a significant positive correlation between bone age and basal and after hCG testosterone was demonstrated; this correlation was not found in the obese boys. The pituitary reserve of gonadotrophins did not show significant differences between the two groups of children. Finally a significant positive correlation (p less than 0.01) between the LH curve area during the LH-RH test and bone age was found only in the normal boys.
对22名正常男孩和35名肥胖男孩进行了性腺功能测试（肌肉注射人绒毛膜促性腺激素，每天2000国际单位，共三天，并在注射前后检测血浆睾酮）。所有“正常矮个”儿童和31名肥胖受试者接受了促黄体生成素释放激素（LH-RH）测试（静脉注射50微克）。两组儿童的基础睾酮水平相似，但肥胖男孩在注射人绒毛膜促性腺激素后睾酮水平显著降低（p<0.001）。在正常儿童中，骨龄与基础睾酮及注射人绒毛膜促性腺激素后的睾酮之间存在显著正相关；而在肥胖男孩中未发现这种相关性。两组儿童促性腺激素的垂体储备无显著差异。最后，仅在正常男孩中发现促黄体生成素释放激素测试期间促黄体生成素曲线面积与骨龄之间存在显著正相关（p<0.01）。
