Schimmel D
Institut für bakterielle Tierseuchenforschung Jena-Zwätzen, Akademie der Landwirtschaftswissenschaften.
Berl Munch Tierarztl Wochenschr. 1990 Nov 1;103(11):384-5.
An acute P. multocida infection led to severe losses in a big Cairina moschata fattening farm. All isolated strains belong to serogroup D. After testing the virulence and immunogenic properties of the isolated strains in NMRI mice, we used an highly virulent and immunogenic strain for developing an inactivated vaccine (formaline inactivated, Al (OH)3 adsorbed, with a content of 3 x 10(9) bacteria/ml). Two sc. immunizations of Cairina at an age of 10 and 24 days resulted in immunity. All immunized animals survived the challenge infection. The immunity was stable till the 8th week after the 2nd immunization, later the intensity of the immunity decreased. A threefold immunization procedure in the Cairina farm was very successful.
一次多杀性巴氏杆菌急性感染导致一个大型麝香鸭育肥场遭受严重损失。所有分离菌株均属于D血清群。在对NMRI小鼠中分离菌株的毒力和免疫原性进行检测后,我们使用一株高毒力和免疫原性的菌株来研制一种灭活疫苗(福尔马林灭活、吸附于氢氧化铝,细菌含量为3×10⁹/ml)。对10日龄和24日龄的麝香鸭进行两次皮下免疫可产生免疫力。所有免疫动物在攻毒感染中存活下来。免疫力在第二次免疫后直至第8周都保持稳定,之后免疫力强度下降。在麝香鸭养殖场进行的三次免疫程序非常成功。