Department of Gastroenterology, Ankara University Faculty of Medicine, Ankara, Turkey.
J Med Virol. 2011 Jun;83(6):974-80. doi: 10.1002/jmv.21747.
The aims of this cohort study were to evaluate the association of malignant lymphoproliferative disorders in patients with chronic viral hepatitis and to compare the results with those in individuals with non-alcoholic fatty liver disease. A total of 3,873 patients with chronic liver disease who were seen consecutively in the Liver Disease Outpatient Clinic between January 2001 and July 2007 were assessed retrospectively. The frequency of malignant lymphoproliferative disorders including non-Hodgkin's lymphoma, Hodgkin's lymphoma, and chronic lymphocytic leukemia in these patients was investigated. Of the total, 1,999 patients had chronic hepatitis B infection (male/female: 1,226/773, mean age: 45.1 ± 13.2 years), 978 had chronic hepatitis C infection (male/female: 437/541, mean age: 53.8 ± 13.7 years), and the remaining 896 had non-alcoholic fatty liver disease (male/female: 450/446, mean age: 50.8 ± 11.2 years). A malignant lymphoproliferative disorder was identified in 13 patients (male/female: 9/4, mean age: 52.8 ± 16.8 years) with chronic viral hepatitis, while no case of malignant lymphoproliferative disorder was identified in individuals with non-alcoholic fatty liver disease (P = 0.048). Among the patients with malignant lymphoproliferative disorders, seven had chronic hepatitis B infection and six had chronic hepatitis C infection; 11 had non-Hodgkin's lymphoma and two had chronic lymphocytic leukemia. All non-Hodgkin's lymphoma cases were B-cell lymphoma. Based on the data obtained in this investigation, the association with malignant lymphoproliferative disorders in chronic viral hepatitis seems to be high as compared to that occurring in individuals with non-alcoholic fatty liver disease.
本队列研究旨在评估慢性病毒性肝炎患者恶性淋巴增生性疾病的发病风险，并与非酒精性脂肪性肝病患者进行比较。回顾性评估了 2001 年 1 月至 2007 年 7 月期间连续在肝病门诊就诊的 3873 例慢性肝病患者。调查了这些患者中包括非霍奇金淋巴瘤、霍奇金淋巴瘤和慢性淋巴细胞白血病在内的恶性淋巴增生性疾病的发病频率。其中，1999 例患者患有慢性乙型肝炎感染（男/女：1226/773，平均年龄：45.1±13.2 岁），978 例患者患有慢性丙型肝炎感染（男/女：437/541，平均年龄：53.8±13.7 岁），其余 896 例患者患有非酒精性脂肪性肝病（男/女：450/446，平均年龄：50.8±11.2 岁）。在患有慢性病毒性肝炎的患者中发现了 13 例（男/女：9/4，平均年龄：52.8±16.8 岁）恶性淋巴增生性疾病，而非酒精性脂肪性肝病患者中未发现恶性淋巴增生性疾病（P=0.048）。在恶性淋巴增生性疾病患者中，7 例患有慢性乙型肝炎感染，6 例患有慢性丙型肝炎感染；11 例患有非霍奇金淋巴瘤，2 例患有慢性淋巴细胞白血病。所有非霍奇金淋巴瘤病例均为 B 细胞淋巴瘤。根据本研究获得的数据，慢性病毒性肝炎患者恶性淋巴增生性疾病的发病风险似乎高于非酒精性脂肪性肝病患者。
