Dolan Elisabeth A
Case Western Reserve University, University Hospitals of Cleveland, OH, 44106, USA.
Am J Hosp Palliat Care. 2011 Dec;28(8):576-82. doi: 10.1177/1049909111406706. Epub 2011 Apr 19.
Malignant bowel obstruction is common in individuals with intra-abdominal and pelvic malignancies and results in considerable suffering. Treatments target both the resolution of obstruction and symptom management. Emerging procedures include stents placement in the bowel to return patency and newer surgical procedures that are evolving to be less invasive. The use of medical interventions like corticosteroids, alone or in concert with additional drugs, can be utilized to achieve resolution of obstruction. Throughout treatment, it is important to also aggressively treat obstructive symptoms like pain and nausea/vomiting. This can mostly be achieved with medications, but use of venting percutaneous endoscopic gastrostomy (PEG) can also relieve symptoms. Parenteral hydration and nutrition use remain controversial with this population. The factor most closely tied to prognosis is performance status.
恶性肠梗阻在腹腔和盆腔恶性肿瘤患者中很常见,会给患者带来极大痛苦。治疗目标包括解除梗阻和症状管理。新兴的治疗方法包括在肠道内放置支架以恢复通畅,以及不断发展的侵入性较小的新型外科手术。使用皮质类固醇等药物干预措施,单独使用或与其他药物联合使用,可用于解除梗阻。在整个治疗过程中,积极治疗疼痛和恶心/呕吐等梗阻症状也很重要。这大多可通过药物实现,但使用经皮内镜下胃造口术(PEG)进行排气也可缓解症状。对于这类患者,肠外补液和营养的使用仍存在争议。与预后关系最密切的因素是体能状态。