Department of Neurology, Knappschaftskrankenhaus, Ruhr-University of Bochum, Bochum, Germany.
Mov Disord. 2011 Mar;26(4):728-30. doi: 10.1002/mds.23439. Epub 2010 Nov 10.
The aim of this study was to test the hypothesis of a fundamental impairment of vocal pace performance in Parkinson's disease (PD) based on a syllable repetition paradigm and the influence of levodopa and deep brain stimulation of the subthalamic nucleus (STN-DBS). Twenty-two PD patients under stable dopaminergic medication, 14 patients with STN-DBS, and 30 controls were tested. Participants had to repeat the syllable /pa/ in a steady pace. Percental coefficient of variance (COV) of interval length was measured for the description of pace stability. Patients were tested in the OFF state and again in the ON state after levodopa administration or ongoing STN-DBS. COV was elevated in both PD subgroups. COV was not influenced by levodopa administration but showed a further deterioration under STN-DBS. The impaired syllable repetition capacity shows similarities to the patterns of more complex speech rhythm abnormalities in PD and therefore might share the same pathophysiology.
本研究旨在通过音节重复范式以及左旋多巴和丘脑底核深部脑刺激（STN-DBS）的影响来检验帕金森病（PD）患者基本发声节奏表现受损的假设。研究纳入了 22 名处于稳定多巴胺能药物治疗的 PD 患者、14 名接受 STN-DBS 治疗的患者和 30 名对照者。参与者需要以稳定的节奏重复音节“pa”。间隔长度的百分比变异系数（COV）用于描述节奏稳定性。患者在停用左旋多巴或持续进行 STN-DBS 的 OFF 状态和 ON 状态下接受测试。两个 PD 亚组的 COV 均升高。COV 不受左旋多巴给药的影响，但在 STN-DBS 下进一步恶化。音节重复能力受损与 PD 中更复杂的言语节律异常模式相似，因此可能具有相同的病理生理学基础。
