Laboratory for Biomolecular Nanotechnology, MESA+ Institute, University of Twente, P.O. Box 207, 7500 AE Enschede, The Netherlands.
J Am Chem Soc. 2011 May 11;133(18):6878-81. doi: 10.1021/ja110752u. Epub 2011 Apr 20.
We report herein the encapsulation of a water-soluble phthalocyanine (Pc) into virus-like particles (VLPs) of two different sizes, depending on the conditions. At neutral pH, the cooperative encapsulation/templated assembly of the particles induces the formation of Pc stacks instead of Pc dimers, due to an increased confinement concentration. The Pc-containing VLPs may potentially be used as photosensitizer/vehicle systems for biomedical applications such as photodynamic therapy.
我们在此报告了一种水溶性酞菁（Pc）在两种不同大小的病毒样颗粒（VLPs）中的包封，这取决于条件。在中性 pH 下，由于受限浓度的增加，颗粒的协同包封/模板组装诱导了 Pc 堆积体的形成，而不是 Pc 二聚体的形成。含有 Pc 的 VLPs 可潜在地用作光动力治疗等生物医学应用的光敏剂/载体系统。
