Tabriz University of Medical Sciences, Biotechnology Research Center and Faculty of Pharmacy, Tabriz 51664, Iran.
Expert Opin Drug Deliv. 2011 Jul;8(7):891-903. doi: 10.1517/17425247.2011.574124. Epub 2011 Apr 21.
Absorption of drugs through the gastrointestinal tract poses a variety of limitations, making the in vivo performance of drug delivery systems uncertain. Following on from recent advances, in a time of increased consideration of floating drug delivery systems, it is as important as ever to continue the progress by studying different aspects of these systems. Moreover, it seems imperative to gain a deeper insight into drug release mechanisms, in order to design a more systematic and intellectual floating system.
This paper summarizes current approaches in the research and development of ideal floating drug delivery systems, from recent literature. Also, in order to have predictability and reproducibility in designing an efficient floating dosage form, some kinetic studies are mentioned, and the drug release mechanism from floating drug delivery systems is discussed.
Developing an efficient floating dosage form is reliant on a better understanding of the relation between formulation variables and performance of the floating systems. Generally, the combination of two buoyancy mechanisms and gas-generating systems with swellable polymers would be beneficial for obtaining an appropriate floating lag time and duration of buoyancy, which in turn guarantees optimum efficiency of the pharmaceutical dosage form.
药物经胃肠道吸收存在多种局限性，这使得药物传递系统的体内性能具有不确定性。在人们越来越多地考虑应用漂浮型药物传递系统的当下，继续通过研究这些系统的不同方面来取得进展与以往同样重要。此外，深入了解药物释放机制似乎势在必行，以便设计出更系统、更智能的漂浮系统。
本文从近期文献中总结了理想漂浮型药物传递系统的研究和开发现状。此外，为了在设计高效漂浮型制剂时具有可预测性和重现性，本文还提到了一些动力学研究，并讨论了漂浮型药物传递系统的药物释放机制。
开发高效的漂浮型制剂依赖于更好地理解制剂变量与漂浮系统性能之间的关系。通常，将两种浮力机制与可膨胀聚合物和产气系统相结合，有利于获得合适的漂浮时滞和漂浮持续时间，从而确保药物制剂的最佳效率。
