Huanbutta Kampanart, Nernplod Tassanee, Akkaramongkolporn Prasert, Sriamornsak Pornsak
Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20131, Thailand.
Pharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.
Asian J Pharm Sci. 2017 May;12(3):227-234. doi: 10.1016/j.ajps.2016.12.002. Epub 2016 Dec 23.
The aim of this study was to design porous matrix beads for floating drug delivery using enteric polymer, Eudragit L and various amounts of waxes (0, 0.1, 0.5, 1, 2 and 3% w/w). In this study, wax containing cetyl alcohol and white petrolatum was utilized to produce pores using a wax removal technique. To prepare the beads, Eudragit L, metronidazole and wax were dissolved in acetone and then extruded into dichloromethane. The effect of the amount of wax on the floating and drug release behavior of the Eudragit L beads was determined. After the extruded product was immersed in dichloromethane, wax dissolved out from the formed beads, resulting in a porous structure. The prepared beads could float in simulated gastric fluid for more than 10 hours. Different amounts of wax had an effect on the drug release. We found that when the percentage of wax increased, the drug release was higher while the beads remained floating. The results suggest that Eudragit L beads could be used as a carrier for an intragastric floating drug delivery system.
本研究的目的是使用肠溶聚合物Eudragit L和各种用量的蜡（0、0.1、0.5、1、2和3% w/w）设计用于漂浮药物递送的多孔基质珠。在本研究中，使用含有十六醇和白凡士林的蜡，通过脱蜡技术产生孔隙。为制备珠子，将Eudragit L、甲硝唑和蜡溶解在丙酮中，然后挤出到二氯甲烷中。测定了蜡用量对Eudragit L珠漂浮和药物释放行为的影响。挤出产物浸入二氯甲烷后，蜡从形成的珠子中溶出，形成多孔结构。制备的珠子可在模拟胃液中漂浮超过10小时。不同用量的蜡对药物释放有影响。我们发现，当蜡的百分比增加时，药物释放量更高，而珠子仍保持漂浮。结果表明，Eudragit L珠可作为胃内漂浮药物递送系统的载体。
