Blusztajn J K, Lopez Gonzalez-Coviella I, Logue M, Growdon J H, Wurtman R J
Department of Pathology, Boston University School of Medicine, MA 02118.
Brain Res. 1990 Dec 17;536(1-2):240-4. doi: 10.1016/0006-8993(90)90030-f.
Concentrations of glycerophosphocholine and of glycerophosphoethanolamine, the metabolites of two major membrane phospholipid classes, phosphatidylcholine and phosphatidylethanolamine respectively, were determined post-mortem in cortical areas 20 and 40 and in cerebellum and caudate nucleus of brains obtained at autopsy from patients with Alzheimer's disease, Down's syndrome and age-matched control subjects. Glycerophosphocholine concentrations in all of the brain regions examined were higher by 67-150% in Alzheimer's disease than in control brains and 81-104% higher in Alzheimer's disease than in Down's syndrome. Glycerophosphoethanolamine concentrations were 21-52% higher in Alzheimer's disease than in controls, and 27-92% higher in Alzheimer's disease than Down's syndrome. Levels of glycerophosphocholine and of glycerophosphoethanolamine did not differ significantly between Down's syndrome and control brains. These data indicate that abnormal phospholipid metabolism in brain is characteristic of Alzheimer's disease but not Down's syndrome and suggest that this abnormality may be a central pathophysiological feature of Alzheimer's disease because levels of glycerophosphocholine and of glycerophosphoethanolamine are elevated in brain regions with and without manifestations of histopathology.
分别测定了磷脂酰胆碱和磷脂酰乙醇胺这两种主要膜磷脂类别的代谢产物甘油磷酸胆碱和甘油磷酸乙醇胺的浓度。这些样本来自于阿尔茨海默病患者、唐氏综合征患者以及年龄匹配的对照受试者的大脑，在尸检时获取大脑的皮质20区和40区、小脑以及尾状核。在所有检测的脑区中，阿尔茨海默病患者的甘油磷酸胆碱浓度比对照大脑高67%-150%，比唐氏综合征患者高81%-104%。阿尔茨海默病患者的甘油磷酸乙醇胺浓度比对照高21%-52%，比唐氏综合征患者高27%-92%。唐氏综合征患者和对照大脑之间的甘油磷酸胆碱和甘油磷酸乙醇胺水平没有显著差异。这些数据表明，大脑中异常的磷脂代谢是阿尔茨海默病的特征，而非唐氏综合征的特征，并且表明这种异常可能是阿尔茨海默病的一个核心病理生理特征，因为在有和没有组织病理学表现的脑区中甘油磷酸胆碱和甘油磷酸乙醇胺的水平都升高了。
