前列腺素与炎症。
Prostaglandins and inflammation.
机构信息
Institute for Translational Medicine and Therapeutics, 153 Johnson Pavilion, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Arterioscler Thromb Vasc Biol. 2011 May;31(5):986-1000. doi: 10.1161/ATVBAHA.110.207449.
Abstract
Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic functions and mediate pathogenic mechanisms, including the inflammatory response. They are generated from arachidonate by the action of cyclooxygenase isoenzymes, and their biosynthesis is blocked by nonsteroidal antiinflammatory drugs, including those selective for inhibition of cyclooxygenase-2. Despite the clinical efficacy of nonsteroidal antiinflammatory drugs, prostaglandins may function in both the promotion and resolution of inflammation. This review summarizes insights into the mechanisms of prostaglandin generation and the roles of individual mediators and their receptors in modulating the inflammatory response. Prostaglandin biology has potential clinical relevance for atherosclerosis, the response to vascular injury and aortic aneurysm.
摘要
前列腺素是源自花生四烯酸的脂质自体活性物质。它们既能维持体内平衡功能，也能介导包括炎症反应在内的致病机制。前列腺素是由环氧化酶同工酶作用于花生四烯酸生成的，其生物合成被非甾体抗炎药阻断，包括那些选择性抑制环氧化酶-2 的药物。尽管非甾体抗炎药具有临床疗效，但前列腺素可能在炎症的发生和消退中发挥作用。这篇综述总结了前列腺素生成机制的研究进展，以及各个介质及其受体在调节炎症反应中的作用。前列腺素生物学对于动脉粥样硬化、血管损伤反应和主动脉瘤具有潜在的临床相关性。
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