过敏炎症和哮喘中的环氧化酶

Cyclooxygenase enzymes in allergic inflammation and asthma.

作者信息

Carey Michelle A, Germolec Dori R, Langenbach Robert, Zeldin Darryl C

机构信息

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive Mail Drop D2-02, Research Triangle Park, NC 27709, USA.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 2003 Aug-Sep;69(2-3):157-62. doi: 10.1016/s0952-3278(03)00076-0.

DOI:10.1016/s0952-3278(03)00076-0

PMID:12895598

Abstract

The cyclooxygenase enzyme system produces eicosanoids which mediate many important physiological and pathological functions. Experimental and clinical data suggest a role for this enzyme system in the pathogenesis of allergic inflammation and asthma. This article focuses on the function of this pathway in the lung, reviews evidence implicating the involvement of this pathway in asthma and allergic airway inflammation, and discusses implications for the treatment of asthmatics with cyclooxygenase inhibitors.

摘要

环氧化酶酶系统产生类花生酸，这些类花生酸介导许多重要的生理和病理功能。实验和临床数据表明该酶系统在过敏性炎症和哮喘的发病机制中起作用。本文重点关注该途径在肺部的功能，综述了表明该途径参与哮喘和过敏性气道炎症的证据，并讨论了使用环氧化酶抑制剂治疗哮喘患者的意义。