Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Anticancer Res. 2011 Apr;31(4):1427-30.
Knowledge of the characteristics and effective use of tumour markers for mesothelioma is essential for early-stage diagnosis of mesothelioma. We examined whether renal dysfunction influences blood concentrations of promising new tumour markers, N-ERC/mesothelin (N-ERC) and osteopontin (OPN), to an important degree.
Levels of serum N-ERC and plasma OPN in 32 patients with chronic renal dysfunction, 22 of whom were on hemodialysis (CKD group), and 102 healthy volunteers were measured.
Serum concentrations of N-ERC and plasma concentrations of OPN in the CKD group were significantly higher than those in volunteers, regardless of diabetes status and age. Blood concentrations of these markers increased as renal function decreased.
N-ERC and OPN concentrations are significantly influenced by renal function. Therefore, the extent of renal failure must be considered when inferring the existence of tumours and chemotherapeutic response from the values of these markers in routine practice.
了解间皮瘤的特征和肿瘤标志物的有效应用对于间皮瘤的早期诊断至关重要。我们研究了肾功能不全是否会对有前途的新型肿瘤标志物 N-ERC/间皮素（N-ERC）和骨桥蛋白（OPN）的血液浓度产生重要影响。
检测了 32 例慢性肾功能不全患者（其中 22 例接受血液透析，即 CKD 组）和 102 名健康志愿者的血清 N-ERC 和血浆 OPN 水平。
无论糖尿病状态和年龄如何，CKD 组的血清 N-ERC 浓度和血浆 OPN 浓度均明显高于志愿者。这些标志物的血液浓度随肾功能下降而升高。
肾功能对 N-ERC 和 OPN 浓度有显著影响。因此，在常规实践中，从这些标志物的数值推断肿瘤的存在和化疗反应时，必须考虑肾衰竭的程度。
