INSERM ERI-21 and Université de Nice Sophia Antipolis, Faculté of Médecine, Nice, France.
Autophagy. 2011 Jul;7(7):786-7. doi: 10.4161/auto.7.7.15595. Epub 2011 Jul 1.
Susceptibility to Crohn disease (CD), an inflammatory bowel disease, is influenced by common variants at many loci like the exonic synonymous IRGM SNP (rs10065172, NM_001145805.1, c.313C>T). We recently showed that miR-196 is overexpressed in the inflammatory intestinal epithelia of individuals with CD and downregulates the IRGM protective (c.313C) but not the risk-associated (c.313T) allele. Eventually, loss of: IRGM/miRNA regulation compromises xenophagy. These results highlight a critical "ménage à trois" in risk susceptibility combining IRGM allele, miRNA and xenophagy.
对克罗恩病（CD）的易感性，一种炎症性肠病，受到许多位置的常见变异的影响，如外显子同义IRGM SNP（rs10065172，NM_001145805.1，c.313C>T）。我们最近表明，miR-196 在 CD 个体的炎症性肠道上皮中过度表达，并下调 IRGM 保护性（c.313C）但不调节风险相关（c.313T）等位基因。最终，IRGM/miRNA 调节的丧失会损害异噬作用。这些结果强调了风险易感性的关键“三人关系”，结合了 IRGM 等位基因、miRNA 和异噬作用。
