鱼类摄入、红细胞脂肪酸与早产。
Fish consumption, erythrocyte fatty acids, and preterm birth.
机构信息
*For a list of other members of the NICHD MFMU, see the Appendix online at http://links.lww.com/AOG/A235. From the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland; The Research Institute at Nationwide Children's Hospital, Columbus, Ohio; the Departments of Obstetrics and Gynecology, at Wake Forest University Health Sciences, Winston-Salem, North Carolina; The George Washington University Biostatistics Center, Washington, DC; University of North Carolina, Chapel Hill, North Carolina; Wayne State University, Detroit, Michigan; University of Utah Health Sciences Center, Salt Lake City, Utah; Columbia University, New York, New York; University of Pittsburgh, Pittsburgh, Pennsylvania; The Ohio State University, Columbus, Ohio; Women and Infants Hospital, Brown University, Providence, Rhode Island; Northwestern University, Chicago, Illinois; Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio; Drexel University College of Medicine, Philadelphia, Pennsylvania; University of Alabama at Birmingham, Birmingham, Alabama; University of Texas at Houston, Houston, Texas; and University of Texas Medical Branch, Galveston, Texas.
出版信息
Obstet Gynecol. 2011 May;117(5):1071-1077. doi: 10.1097/AOG.0b013e31821645dc.
OBJECTIVE
To estimate the association between fish consumption and erythrocyte omega-3 long-chain polyunsaturated fatty acids and preterm birth in a high-risk cohort.
METHODS
This was an ancillary study to a randomized trial of omega-3 supplementation to prevent preterm birth in women with at least one previous spontaneous preterm delivery. Dietary fish intake was assessed by questionnaire and erythrocyte fatty acids were measured at enrollment (16-21 completed weeks of gestation). The association between fish consumption and preterm delivery was modeled with linear and quadratic terms.
RESULTS
The probability of preterm birth was 48.6% among women eating fish less than once a month and 35.9% among women eating fish more often (P<.001). The adjusted odds ratio for preterm birth among women reporting moderately frequent fish consumption (three servings per week) was 0.60 (95% confidence interval 0.38-0.95), with no further reduction in preterm birth among women who consumed more than three servings of fish per week. Erythrocyte omega-3 levels correlated weakly but significantly with frequency of fish intake (Spearman r=0.22, P<.001); women in the lowest quartile of erythrocyte omega-3 levels were more likely to report consuming less than one fish meal per month (40.3%) than were women in the highest three quartiles (26.3%, P<.001).
CONCLUSION
Moderate fish intake (up to three meals per week) before 22 weeks of gestation was associated with a reduction in repeat preterm birth. More than moderate consumption did not confer additional benefit. These results support the recommendations of the U.S. Food and Drug Administration and the American Congress of Obstetricians and Gynecologists for fish consumption during pregnancy.
CLINICAL TRIAL REGISTRATION
ClinicalTrials.gov, www.clinicaltrials.gov, NCT00135902.
目的
在高危队列中评估鱼类摄入量与红细胞 ω-3 长链多不饱和脂肪酸和早产之间的关联。
方法
这是一项 ω-3 补充剂预防有至少一次自发性早产史的女性早产的随机试验的辅助研究。通过问卷评估膳食鱼类摄入量，在入组时（妊娠 16-21 周）测量红细胞脂肪酸。采用线性和二次项模型研究鱼类摄入量与早产的关系。
结果
每月食用鱼少于一次的女性早产的概率为 48.6%，而每月食用鱼多于一次的女性早产的概率为 35.9%（P<.001）。报告经常食用鱼类（每周三份）的女性早产的调整比值比为 0.60（95%置信区间 0.38-0.95），每周食用鱼超过三份的女性早产率没有进一步降低。红细胞 ω-3 水平与鱼类摄入量的频率呈弱但显著相关（Spearman r=0.22，P<.001）；红细胞 ω-3 水平最低四分位数的女性更有可能报告每月食用少于一份鱼餐（40.3%），而最高三分位的女性为 26.3%（P<.001）。
结论
妊娠 22 周前适度摄入鱼类（每周不超过三份）与降低复发性早产有关。超过适度摄入量并不能带来额外的益处。这些结果支持美国食品和药物管理局和美国妇产科医师学会关于妊娠期间食用鱼类的建议。
临床试验注册
ClinicalTrials.gov，www.clinicaltrials.gov，NCT00135902。
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