Lin'kova N S, Poliakova V O, Trofimov A V, Sevost'ianova N N, Kvetnoĭ I M
Adv Gerontol. 2010;23(4):543-6.
The interference between thymus and pineal gland during their involution is considered in this review. The research data about influence of thymus peptides on pineal gland and pineal peptides on thymus is summarized. Analysis of these data showed that pineal peptides (epithalamin, epitalon) had more effective geroprotective effect on thymus involution in comparison with geroprotective effect of thymic peptides (thymalin, thymogen) on involution of pineal gland. The key mechanisms of pineal peptides effect on thymus dystrophy is immunoendocrine cooperation, which is realized as transcription's activation of various proteins.
本综述探讨了胸腺和松果体在退化过程中的相互干扰。总结了胸腺肽对松果体以及松果体肽对胸腺影响的研究数据。对这些数据的分析表明，与胸腺肽（胸腺素、胸腺生成素）对松果体退化的保护作用相比，松果体肽（表褪黑素、表褪黑素原）对胸腺退化具有更有效的保护作用。松果体肽对胸腺萎缩作用的关键机制是免疫内分泌协同作用，这一作用通过多种蛋白质转录激活得以实现。
