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胸腺与松果体的功能统一性及衰老机制研究

Functional unity of the thymus and pineal gland and study of the mechanisms of aging.

作者信息

Polyakova V O, Linkova N S, Kvetnoy I M, Khavinson V Kh

机构信息

St. Petersburg Institute of Bioregulation and Gerontology, North Western Division of the Russian Academy of Medical Sciences, Russia.

出版信息

Bull Exp Biol Med. 2011 Sep;151(5):627-30. doi: 10.1007/s10517-011-1400-2.

DOI:10.1007/s10517-011-1400-2
PMID:22462063
Abstract

The data on the morphology and functions of the thymus and pineal gland in individuals of different age are analyzed and common mechanisms of involution of these organs during aging and the consequencies of this process are discussed. Based on the data on the molecular changes in the thymus and pineal gland during aging, the authors hypothesize the functional unity of these organs and their mutual complementarity in the maintenance of normal immune and endocrine status during aging.

摘要

分析了不同年龄段个体胸腺和松果体的形态学及功能数据,并探讨了这些器官在衰老过程中退化的共同机制及其后果。基于衰老过程中胸腺和松果体分子变化的数据,作者推测这些器官在维持衰老过程中正常免疫和内分泌状态方面的功能统一性及其相互补充性。

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Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing.胸腺-松果腺轴:重新探讨其在人类生命和衰老中的作用。
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Temporal expression patterns of the melatoninergic system in the human thymus of children.褪黑素能神经系统在儿童胸腺中的时间表达模式。
Mol Metab. 2019 Oct;28:83-90. doi: 10.1016/j.molmet.2019.07.007. Epub 2019 Jul 24.
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Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging.松果体与胸腺的形态功能及信号分子重叠:在衰老中的作用及意义
Oncotarget. 2016 Mar 15;7(11):11972-83. doi: 10.18632/oncotarget.7863.