Kuwabara Hiroshi, Goseki Narihide, Nakamura Hiroshi, Tamai Satoru, Baba Hiroyuki, Nakajima Kazumi
Department of Surgery, Shuwa General Hospital, 1200, Yaharashinden, Kasukabe, Saitama, 344-0035, Japan.
Hepatogastroenterology. 2011 Jan-Feb;58(105):31-5.
BACKGROUND/AIMS: Appropriateness of the vitamin doses in Japanese commercial multi-vitamin preparations for parenteral nutrition therapy was investigated in patients with gastrointestinal tract disorder by evaluating the vitamin status (blood concentrations and urinary excretions of vitamins B1, B2, B6, and C) of them.
Commercial multivitamin preparations were administered continuously with a commercial PN solution over 5 days to 10 patients with gastrointestinal tract disorder. Blood concentrations of vitamins B1, B2, B6, and C were measured on the mornings of day 1, day 4, and day 6. Urinary excretions were measured in 24-h urine collections collected after day 3 and after day 5.
Blood concentrations of vitamins B1, B2, and B6 increased but remained within or slightly above the normal throughout the study, and urinary excretion values were normal in all patients. However, blood vitamin C concentration surpassed the lower limit of normal (5.5 microg/mL) only on day 6. Urinary vitamin C excretion was below normal (20.0 mg/day) in all and 7 patients on days 3 and 5, respectively.
In patients with gastrointestinal tract disorder, the doses of vitamins B1, B2, and B6 of Japanese commercial multi-vitamin preparations are adequate but that of vitamin C (100 mg/day) is inadequate and should be increased.
背景/目的：通过评估胃肠道疾病患者的维生素状态（维生素B1、B2、B6和C的血药浓度及尿排泄量），研究日本市售用于肠外营养治疗的多种维生素制剂中维生素剂量的适宜性。
将市售多种维生素制剂与市售肠外营养溶液连续给予10例胃肠道疾病患者，持续5天。在第1天、第4天和第6天上午测定维生素B1、B2、B6和C的血药浓度。在第3天和第5天后收集的24小时尿液中测定尿排泄量。
在整个研究过程中，维生素B1、B2和B6的血药浓度升高，但仍在正常范围内或略高于正常范围，所有患者的尿排泄值均正常。然而，仅在第6天血维生素C浓度超过正常下限（5.5微克/毫升）。在第3天和第5天，所有患者和分别有7例患者的尿维生素C排泄低于正常水平（20.0毫克/天）。
在胃肠道疾病患者中，日本市售多种维生素制剂中维生素B1、B2和B6的剂量是足够的，但维生素C（100毫克/天）的剂量不足，应增加。
