霍乱毒素的腺苷酸环化酶激活活性与烟酰胺-腺嘌呤二核苷酸糖水解酶活性无关。
The adenylate cyclase-activating activity of cholera toxin is not associated with a nicotinamide--adenine dinucleotide glycohydrolase activity.
作者信息
Tait R M, van Heyningen S
出版信息
Biochem J. 1978 Sep 15;174(3):1059-62. doi: 10.1042/bj1741059.
Abstract
The NAD+ glycohydrolase activity of cholera-toxin samples can be separated from their adenylate cyclase-activating activity by polyacrylamide-gel electrophoresis and is inhibited by sodium dodecyl sulphate (which does not inhibit the action of toxin on cells), but not by antibodies to pure toxin. It is therefore probably not a true property of the toxin.
摘要
霍乱毒素样本的NAD⁺ 糖水解酶活性可通过聚丙烯酰胺凝胶电泳与其激活腺苷酸环化酶的活性分离，且该活性受到十二烷基硫酸钠的抑制（十二烷基硫酸钠并不抑制毒素对细胞的作用），但不受纯毒素抗体的抑制。因此，这可能并非毒素的真正特性。
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