Iuchi K, Kiyokawa H, Ishikawa T, Kaseno K
Department of Internal Medicine, Toyama Prefectural Hospital.
J Cardiol. 1990;20(1):95-101.
This study was performed to investigate the characteristics of isovolumic relaxation flow velocity (IRFV) in the mid-portion of the left ventricle. Doppler examinations were performed at rest in 20 subjects with normal heart and 18 with hypertrophic heart disease. To assess the left ventricular flow conditions in hyperdynamic states, 10 healthy subjects underwent exercise Doppler echocardiography. From the apical transducer position, left ventricular filling velocities were obtained at the mitral valve orifice level and at the mid-ventricle, and the changes of peak velocities in the rapid filling (R0, R1) and atrial contraction phases (A0, A1) were measured [%R = (R1-R0)/R0, %A = (A1-A0)/A0]. There was a good correlation between IRFV and %R (IRFV = 0.69 X %R + 25.9, r = 0.75, p less than 0.001). However, there was no correlation between IRFV and %A. Prominent IRFV (greater than or equal to 30 cm/sec) was demonstrated in 13 subjects, including 10 with hypertrophic heart disease. During exercise, IRFV, %R and %A did not increase. It was concluded that a prominent IRFV was associated with the acceleration of rapid filling velocity at the mid-ventricle. This phenomenon may be caused by regional and asynchronous hyperdynamic states demonstrated in hypertrophic heart disease.
本研究旨在探讨左心室中部等容舒张期血流速度（IRFV）的特征。对20名心脏正常的受试者和18名肥厚性心脏病患者在静息状态下进行了多普勒检查。为评估高动力状态下的左心室血流情况，对10名健康受试者进行了运动多普勒超声心动图检查。从心尖换能器位置，在二尖瓣口水平和心室中部获取左心室充盈速度，并测量快速充盈期（R0、R1）和心房收缩期（A0、A1）峰值速度的变化[％R =（R1 - R0）/ R0，％A =（A1 - A0）/ A0]。IRFV与％R之间存在良好的相关性（IRFV = 0.69×％R + 25.9，r = 0.75，p＜0.001）。然而，IRFV与％A之间无相关性。13名受试者（包括10名肥厚性心脏病患者）表现出显著的IRFV（≥30cm/秒）。运动期间，IRFV、％R和％A未增加。得出的结论是，显著的IRFV与心室中部快速充盈速度的加快有关。这种现象可能是由肥厚性心脏病中表现出的局部和异步高动力状态引起的。
