Chiari I型畸形与脊髓空洞症的发病机制。
The pathogenesis of Chiari I malformation and syringomyelia.
作者信息
Sekula Raymond F, Arnone Gregory D, Crocker Christine, Aziz Khaled M, Alperin Noam
机构信息
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
出版信息
Neurol Res. 2011 Apr;33(3):232-9. doi: 10.1179/016164111X12962202723724.
OBJECTIVE
The pathogeneses of Chiari malformation type I and syringomyelia are incompletely understood. In this article, the authors attempt to review the current theories on the pathogeneses of Chiari I malformation and syringomyelia.
METHODS
A literature review for articles pertaining to Chiari I malformation or syringomyelia before August 2010 was conducted; in addition, the author's own experience in treating Chiari I malformation and syringomyelia is included.
RESULTS
Chiari I malformation has been defined radiographically as cerebellar tonsillar herniation or ectopia 5 mm or greater below the foramen magnum. By this narrow definition, Chiari I malformation (i.e. cerebellar tonsillar herniation or ectopia 5 mm or greater below the foramen magnum) likely encompasses a heterogeneous grouping of disorders caused by different mechanisms. Molecular and genetic studies have been helpful in furthering our understanding of Chiari I malformation.
CONCLUSION
A review of the pathogeneses of Chiari I malformation and syringomyelia is reported.
目的
I型Chiari畸形和脊髓空洞症的发病机制尚未完全明确。在本文中，作者试图对目前关于I型Chiari畸形和脊髓空洞症发病机制的理论进行综述。
方法
对2010年8月之前有关I型Chiari畸形或脊髓空洞症的文章进行文献综述；此外，还纳入了作者自身治疗I型Chiari畸形和脊髓空洞症的经验。
结果
I型Chiari畸形在影像学上被定义为小脑扁桃体疝或枕大孔以下5毫米或更大程度的异位。按照这个狭义的定义，I型Chiari畸形（即小脑扁桃体疝或枕大孔以下5毫米或更大程度的异位）可能涵盖了由不同机制引起的一组异质性疾病。分子和遗传学研究有助于加深我们对I型Chiari畸形的理解。
结论
报道了对I型Chiari畸形和脊髓空洞症发病机制的综述。
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