2 型糖尿病患者的糖尿病周围神经病变与动脉僵硬度增加有关，而颈动脉内膜中层厚度无变化。
Diabetic peripheral neuropathy is associated with increased arterial stiffness without changes in carotid intima-media thickness in type 2 diabetes.
机构信息
Division of Endocrinology, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea.
出版信息
Diabetes Care. 2011 Jun;34(6):1403-5. doi: 10.2337/dc10-2222. Epub 2011 Apr 22.
Abstract
OBJECTIVE
This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima-media thickness (IMT).
RESEARCH DESIGN AND METHODS
We conducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathic symptoms, insensitivity to a 10-g monofilament, abnormal pin-prick sensation, and abnormal current perception threshold. Arterial stiffness was assessed by cardio-ankle vascular index (CAVI), and IMT was assessed by B-mode ultrasonography.
RESULTS
Patients with DPN had higher CAVI than those without DPN in multivariate-adjusted models, whereas no differences in IMT were observed between patients with and without DPN after adjustment for age and sex. In the multivariate analysis, CAVI was a significant determinant of DPN (odds ratio 1.36 [95% CI 1.13-1.65], P = 0.001).
CONCLUSIONS
DPN is significantly associated with arterial stiffness without carotid intimal changes in patients with type 2 diabetes.
摘要
目的
本研究旨在探讨糖尿病周围神经病变（DPN）与动脉僵硬度和内膜中层厚度（IMT）的关系。
研究设计和方法
我们对 731 例 2 型糖尿病患者进行了横断面分析。DPN 的诊断基于神经病变症状、10g 单丝感觉丧失、异常刺痛感和异常电流感知阈值。通过心血管踝血管指数（CAVI）评估动脉僵硬度，通过 B 型超声评估 IMT。
结果
在多变量调整模型中，患有 DPN 的患者的 CAVI 高于没有 DPN 的患者，而在调整年龄和性别后，患有和不患有 DPN 的患者之间的 IMT 没有差异。在多变量分析中，CAVI 是 DPN 的一个显著决定因素（比值比 1.36 [95%CI 1.13-1.65]，P = 0.001）。
结论
在 2 型糖尿病患者中，DPN 与动脉僵硬度显著相关，而与颈动脉内膜变化无关。
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