Bowness J M
Atherosclerosis. 1978 Dec;31(4):403-8. doi: 10.1016/0021-9150(78)90135-1.
Gradient density ultracentrifugation was used to assess the lipid binding of 125I-labelled structural glycoproteins and standard proteins. The results show that solubilized structural glycoproteins from cartilage or aorta will associate spontaneously with lipids or lipoproteins. In addition, structural glycoprotein preparations from tissues which have not been delipidated contain a fraction which is already associated with lipid. Standard proteins do not behave in the same way. It is proposed that structural glycoprotein-lipid binding may be one of the mechanisms involved in the intercellular deposition of plasma lipoproteins in atherosclerotic arteries.
采用梯度密度超速离心法评估125I标记的结构糖蛋白和标准蛋白与脂质的结合情况。结果表明，从软骨或主动脉中溶解出来的结构糖蛋白会自发地与脂质或脂蛋白结合。此外，来自未进行脱脂处理的组织的结构糖蛋白制剂中含有一部分已经与脂质结合的成分。标准蛋白则不会表现出同样的行为。有人提出，结构糖蛋白与脂质的结合可能是动脉粥样硬化动脉中血浆脂蛋白细胞间沉积所涉及的机制之一。
