Falcone D J, Hajjar D P, Minick C R
Am J Pathol. 1984 Jan;114(1):112-20.
Although arterial injury is believed to be an important factor in the pathogenesis of atherosclerosis, little is known about lipoprotein accumulation in the injured arterial wall. In experiments reported here, the authors quantitated the accumulation of iodinated lipoprotein and albumin in reendothelialized and deendothelialized rabbit aorta. Results indicate that over the experimental period, insudated lipoprotein but not albumin is retained in the reendothelialized aorta. Neither lipoprotein nor albumin was retained in the adjacent persistently deendothelialized aorta. Findings are consistent with the hypothesis that sequestration of lipoprotein in reendothelialized artery is one mechanism by which lipid accumulates in these areas.
虽然动脉损伤被认为是动脉粥样硬化发病机制中的一个重要因素，但关于脂蛋白在受损动脉壁中的蓄积情况却知之甚少。在本文报道的实验中，作者对再内皮化和去内皮化兔主动脉中碘化脂蛋白和白蛋白的蓄积进行了定量分析。结果表明，在实验期间，渗入的脂蛋白而非白蛋白保留在再内皮化的主动脉中。脂蛋白和白蛋白均未保留在相邻的持续去内皮化的主动脉中。这些发现与以下假设一致，即再内皮化动脉中脂蛋白的隔离是脂质在这些区域蓄积的一种机制。
