Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.
Clin Endocrinol (Oxf). 2011 Jun;74(6):776-82. doi: 10.1111/j.1365-2265.2011.04011.x.
The aim of this study was to evaluate the overall ultrasonographic features and clinical factors that contribute to inadequate sampling in ultrasound-guided fine-needle aspiration biopsy (US-FNAB) of thyroid nodules.
From April 2008 to December 2008, 4077 US-FNABs in 3767 consecutive patients were reviewed. We evaluated the clinical, ultrasound and pathological features of patients and analysed the association between these features and inadequate samples. We also compared inadequate sample rates according to the experience of the performing doctor.
The inadequate sample rate was 16·1% (654/4077). Univariate analysis revealed an association between inadequate samples and cyst dominancy, macrocalcification and benign pathology of the nodule. The inadequate sample rate was also higher in the inexperienced group than in the experienced group. In multivariate analysis, cyst dominancy and macrocalcification of a nodule were significantly associated with inadequate samples in the experienced group.
Cyst dominancy and macrocalcifications in thyroid nodules, inexperience of the performing doctor and benign pathology were factors associated with high inadequate sample rates of US-FNAB in thyroid nodules.
本研究旨在评估超声引导下细针抽吸活检（US-FNAB）甲状腺结节中导致样本不足的总体超声特征和临床因素。
回顾性分析 2008 年 4 月至 2008 年 12 月期间 3767 例连续患者的 4077 例 US-FNAB。评估患者的临床、超声和病理特征，并分析这些特征与样本不足之间的关系。还根据操作医生的经验比较了样本不足率。
样本不足率为 16.1%（654/4077）。单因素分析显示，样本不足与结节中囊肿为主、大钙化和良性病理有关。经验不足组的样本不足率也高于经验丰富组。多因素分析显示，经验丰富组中结节的囊肿为主和大钙化与样本不足显著相关。
甲状腺结节中囊肿为主、大钙化、操作医生经验不足和良性病理是与 US-FNAB 甲状腺结节样本不足率高相关的因素。
