Skin Research Center, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Eur Acad Dermatol Venereol. 2012 May;26(5):654-6. doi: 10.1111/j.1468-3083.2011.04088.x. Epub 2011 Apr 27.
Thyroid hormone receptors are expressed in hair follicles and it is known that thyroid hormones can have a positive effect on hair growth, i.e. process which is disrupted in alopecia areata.
The aim of this study was to determine the efficacy of topical triiodothyronine in patients with patchy alopecia areata.
Ten patients with patchy alopecia areata were treated with triiodothyronine and placebo applied twice daily to either of two bilaterally symmetrical patches for 12 weeks. The two sides were randomly assigned following simple randomization procedure to one of the two treatment groups. The patients and the investigator were blinded to the content of the tubes. Hair regrowth was evaluated every 4 weeks. Blood samples for measurements of complete blood count along with thyroid function (T3, T4 and TSH) and liver function tests were taken at the baseline and at the end of study.
After 12 weeks of treatment, there was no statistically significant difference between the outcome in terms of reduction of the patch size and hair regrowth. No adverse effects were noted.
Triiodothyronine in the studied dosage and formulation was safe but not more effective than placebo. However, newer thyroid hormone analogues might be more effective and evaluating their effects probably warrants further consideration.
甲状腺激素受体存在于毛囊中，已知甲状腺激素对毛发生长有积极作用，即在斑秃中被打乱的过程。
本研究旨在确定局部三碘甲状腺原氨酸在斑片状斑秃患者中的疗效。
10 名斑片状斑秃患者接受三碘甲状腺原氨酸治疗，安慰剂每天两次应用于双侧两个对称斑块，持续 12 周。根据简单随机化程序，将两侧随机分配到两个治疗组之一。患者和研究者对管内内容物均不知情。每 4 周评估一次毛发再生情况。在基线和研究结束时采集全血细胞计数以及甲状腺功能（T3、T4 和 TSH）和肝功能检查的血样。
治疗 12 周后，斑块大小缩小和毛发再生的结果在统计学上没有显著差异。未观察到不良反应。
研究中使用的三碘甲状腺原氨酸剂量和制剂是安全的，但不如安慰剂有效。然而，新型甲状腺激素类似物可能更有效，评估它们的效果可能需要进一步考虑。
