Al Hammadi Anwar, Parmar Nisha V, Aljefri Khadija, Al Sharif Osama, Abdallah Marwa, Ahmed Haytham Mohamed, Ammoury Alfred
Department of Dermatology, Dermamed Clinic, Dubai, UAE.
Department of Dermatology, Rashid Hospital, Dubai Health Authority, Dubai, UAE.
Dermatol Ther (Heidelb). 2023 Jul;13(7):1435-1464. doi: 10.1007/s13555-023-00946-8. Epub 2023 Jun 20.
Alopecia areata (AA) is an autoimmune disease characterized by non-scarring hair loss in adults and children. Clinical manifestations range from hair loss in small, well-circumscribed patches to total hair loss on the scalp or any other hair-bearing areas. Although the exact pathogenesis of AA is not fully understood, it is thought that loss of immune privilege caused by immunological dysregulation of the hair follicle is key. Genetic susceptibility also plays a role. Response to currently available treatments is widely variable, causing patient dissatisfaction and creating an unmet need. AA is frequently associated with multiple comorbidities, further affecting patient quality of life.
AA causes a significant burden on dermatologists and healthcare systems in the Middle East and Africa. There is a lack of data registries, local consensus, and treatment guidelines in the region. Limited public awareness, availability of treatments, and patient support need to be addressed to improve disease management in the region. A literature review was conducted to identify relevant publications and highlight regional data on prevalence rates, diagnosis, quality of life, treatment modalities, and unmet needs for AA in the Middle East and Africa.
斑秃（AA）是一种自身免疫性疾病，其特征为成人和儿童出现非瘢痕性脱发。临床表现范围从边界清晰的小片状脱发到头皮或任何其他有毛发区域的全秃。尽管AA的确切发病机制尚未完全明确，但人们认为毛囊免疫调节异常导致的免疫豁免丧失是关键因素。遗传易感性也起作用。对现有治疗方法的反应差异很大，导致患者不满，存在未满足的需求。AA常与多种合并症相关，进一步影响患者生活质量。
AA给中东和非洲的皮肤科医生及医疗系统带来了沉重负担。该地区缺乏数据登记、当地共识和治疗指南。需要解决公众意识有限、治疗可及性以及患者支持等问题，以改善该地区的疾病管理。进行了一项文献综述，以识别相关出版物，并突出中东和非洲地区关于AA患病率、诊断、生活质量、治疗方式及未满足需求的区域数据。
