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产金属β-内酰胺酶 VIM-14 的铜绿假单胞菌临床分离株

A novel VIM-type metallo-beta-lactamase (VIM-14) in a Pseudomonas aeruginosa clinical isolate from a neonatal intensive care unit.

机构信息

Dipartimento di Patologia e Diagnostica, Università di Verona, Verona, Italy.

出版信息

Clin Microbiol Infect. 2011 May;17(5):722-4. doi: 10.1111/j.1469-0691.2010.03424.x. Epub 2010 Dec 14.

DOI:10.1111/j.1469-0691.2010.03424.x
PMID:21521413
Abstract

A Pseudomonas aeruginosa highly resistant to carbapenems was isolated in a neonatal intensive care unit in Palermo, Italy. The strain was found to carry a novel VIM-type enzyme, classified as VIM-14. The novel enzyme differs from VIM-4 in a G31S mutation. VIM-14 was harboured in a class 1 integron with a new organization. The integron carried the genes aac7, blaVIM-14, blaOXA-20 and aac4 in that order.

摘要

意大利巴勒莫一家新生儿重症监护病房中分离到一株对碳青霉烯类高度耐药的铜绿假单胞菌。该菌株携带一种新型 VIM 型酶，被归类为 VIM-14。新型酶与 VIM-4 的区别在于 G31S 突变。VIM-14 位于一个新组织的 1 类整合子中。该整合子按顺序携带 aac7、blaVIM-14、blaOXA-20 和 aac4 基因。

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