Institute of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Division of Cardiovascular Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Nutr Metab (Lond). 2011 Apr 26;8(1):25. doi: 10.1186/1743-7075-8-25.
Sphingomyelin (SM) is an abundant phospholipid in cell membranes and in lipoproteins. In human plasma, SM is mainly found in atherogenic lipoproteins; therefore, higher levels of SM may promote atherogenesis. We investigated the relations between plasma SM levels and the presence of angiographic coronary heart disease (CHD) and left ventricular systolic dysfunction. We studied 732 patients referred for coronary angiography. Median SM levels were higher among patients with CHD and in those with LV systolic dysfunction (LVEF<50%) than in patients without CHD or LV dysfunction. SM levels were significantly correlated with fibrinogen levels, diabetes, apoB, and triglyceride levels. On multivariate analyses, higher median SM levels were associated with a higher risk of CHD and lower LV ejection fraction. The pro-atherogenic property of plasma SM might be related to 1) CHD; 2) LV systolic dysfunction; and 3) metabolism of apoB-containing or triglyceride-rich lipoproteins.
鞘磷脂 (SM) 是细胞膜和脂蛋白中的一种丰富的磷脂。在人血浆中，SM 主要存在于动脉粥样硬化脂蛋白中；因此，较高的 SM 水平可能会促进动脉粥样硬化的发生。我们研究了血浆 SM 水平与血管造影冠心病 (CHD) 和左心室收缩功能障碍的存在之间的关系。我们研究了 732 名接受冠状动脉造影的患者。与无 CHD 或左心室功能障碍的患者相比，CHD 患者和左心室收缩功能障碍（LVEF<50%）患者的 SM 水平中位数更高。SM 水平与纤维蛋白原水平、糖尿病、载脂蛋白 B 和甘油三酯水平显著相关。在多变量分析中，较高的 SM 水平中位数与 CHD 风险增加和左心室射血分数降低相关。血浆 SM 的致动脉粥样硬化特性可能与以下三个方面有关：1）CHD；2）LV 收缩功能障碍；3）载脂蛋白 B 或富含甘油三酯脂蛋白的代谢。
