Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland.
J Antimicrob Chemother. 2011 May;66 Suppl 4:iv17-iv21. doi: 10.1093/jac/dkr073.
Current concerns about multiresistance and a diminishing antibiotic pipeline are mainly addressed to Gram-negative bacteria. The greatest fear within the Gram-positive arena is vancomycin-resistant Staphylococcus aureus. Its epidemiology and clinical presentation give cause for concern, but so far its impact has been strictly limited. While this may change, the loss of glycopeptides as a treatment option may not, in fact, be all bad news.
目前人们主要关注革兰氏阴性菌的多重耐药性和不断减少的抗生素种类。在革兰氏阳性菌领域，人们最担心的是耐万古霉素的金黄色葡萄球菌。它的流行病学和临床表现令人担忧，但到目前为止，它的影响是有限的。虽然这种情况可能会改变，但糖肽类药物作为一种治疗选择的丧失实际上可能并非全是坏消息。
