Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
J Cereb Blood Flow Metab. 2011 Jul;31(7):1583-7. doi: 10.1038/jcbfm.2011.61. Epub 2011 Apr 27.
Reinstatement of perilesional activation and connectivity may underlie functional recovery after stroke. To measure activation responsiveness in perilesional cortex in relation to white matter integrity, we performed functional functional magnetic resonance imaging during stimulation of the contralesional cortex, together with diffusion tensor imaging, 3 and 28 days after stroke in rats. Despite disturbed sensorimotor function and abnormal callosal appearance at day 3, activation amplitudes were preserved in the perilesional sensorimotor cortex, although time-to-peak was significantly delayed. This indicates that in spite of dysfunction, perilesional cortical tissue can be activated subacutely after stroke, while delay of the hemodynamic activation response suggests impaired neurovascular coupling.
病灶周围区域的激活和连接的恢复可能是中风后功能恢复的基础。为了测量病灶周围皮质的激活反应与白质完整性的关系，我们在大鼠中风后 3 天和 28 天进行了对侧皮质刺激的功能磁共振成像，同时进行了弥散张量成像。尽管在第 3 天感觉运动功能受损，胼胝体外观异常，但病灶周围感觉运动皮质的激活幅度仍然保留，尽管峰值时间明显延迟。这表明，尽管存在功能障碍，但病灶周围皮质组织在中风后可以在亚急性期被激活，而血液动力学激活反应的延迟表明神经血管耦联受损。
