Van Dyke T E, Hoop G A
Department of Periodontology at Emory University School of Postgraduate Dentistry in Atlanta, Georgia.
Crit Rev Oral Biol Med. 1990;1(2):117-33. doi: 10.1177/10454411900010020201.
The pathological sequela of reduced neutrophil function in the oral cavity and the mechanisms behind dysfunction have added to our understanding of infectious diseases. Numerous examples have been given, and the overriding conclusion must be that any impairment of neutrophil function will lead to some degree of increased susceptibility to infection. Perhaps the tissue most sensitive to pathological changes in the oral cavity is the periodontium. In cases of severe neutrophil dysfunction, there is severe periodontal breakdown, but also in cases of "mild" neutrophil dysfunction, where there is no other infection, such as in individuals with LJP, there is severe periodontal breakdown. The molecular basis of neutrophil dysfunction is beginning to be understood in individuals with LJP, LAD, CGD, and AIDS. It is our hope that further research in this area will help to delineate the pathogenesis of these and other oral diseases.
口腔中中性粒细胞功能降低的病理后遗症以及功能障碍背后的机制，增进了我们对传染病的理解。已经给出了许多例子，而且首要结论必定是中性粒细胞功能的任何损害都会导致某种程度的感染易感性增加。也许口腔中对病理变化最敏感的组织是牙周组织。在严重中性粒细胞功能障碍的病例中，会出现严重的牙周破坏，但在“轻度”中性粒细胞功能障碍的病例中，即在没有其他感染的情况下，如在莱-纳二氏综合征患者中，也会出现严重的牙周破坏。在莱-纳二氏综合征、白细胞黏附缺陷症、慢性肉芽肿病和艾滋病患者中，中性粒细胞功能障碍的分子基础正开始被人们所了解。我们希望在这一领域的进一步研究将有助于阐明这些及其他口腔疾病的发病机制。
