Van Dyke T E, Levine M J, Genco R J
J Oral Pathol. 1985 Feb;14(2):95-120. doi: 10.1111/j.1600-0714.1985.tb00474.x.
The pathologic sequela of reduced neutrophil function have been reviewed. In each case, the mechanism for the reduction in function has been elaborated when known. Special emphasis has been placed upon the pathologic changes in the oral cavity as a result of neutrophil dysfunction. Numerous examples have been given, and the overriding conclusion must be that any impairment of neutrophil function will lead to some degree of increased susceptibility to infection. Perhaps the tissue most sensitive to pathologic changes in the oral cavity is the periodontium. In cases of severe neutrophil dysfunction there is severe periodontal breakdown. But also in cases of "mild" neutrophil dysfunction, where there is no other infection, such as in individuals with LJP, there is severe periodontal breakdown. The molecular basis of neutrophil dysfunction is beginning to be understood in individuals with LJP. It is our hope that further research in this area will help to delineate the pathogenesis of periodontal diseases.
中性粒细胞功能降低的病理后遗症已得到综述。在每种情况下，已知功能降低的机制都已详细阐述。特别强调了中性粒细胞功能障碍导致的口腔病理变化。已给出大量实例，而首要结论必定是中性粒细胞功能的任何损害都会导致某种程度的感染易感性增加。口腔中对病理变化最敏感的组织可能是牙周组织。在严重中性粒细胞功能障碍的病例中，会出现严重的牙周破坏。但在“轻度”中性粒细胞功能障碍的病例中，即使没有其他感染，如在携带LJP的个体中，也会出现严重的牙周破坏。LJP患者中性粒细胞功能障碍的分子基础正逐渐被了解。我们希望该领域的进一步研究将有助于阐明牙周疾病的发病机制。
