Department of Orthopedic Surgery, Hôpital Cochin, Paris-Descartes University, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France.
Osteoporos Int. 2011 Jun;22(6):2011-5. doi: 10.1007/s00198-011-1613-2.
Distraction osteogenesis (DO) is a surgical technique widely used in orthopedic surgery for the treatment of various pathological conditions such as leg length discrepancy, bone deformity or bone defects. The basic principle of the callotasis technique includes performing a transverse bone section before gradually distracting the two bone segments. New bone tissue is generated in the gap between the two segments. Bone regeneration during DO is believed to occur in response to the longitudinal mechanical strain applied to the callus during healing. One of the limitations of this technique is the long period of time required for the newly formed bone tissue to mineralize and consolidate. Various studies have reported that among growth factors, bone morphogenetic proteins (BMPs) may play a central role in the molecular signaling cascade leading to bone renegeration and remodeling in a DO procedure. Ongoing research is aimed at developing methods to accelerate bone consolidation in order to reduce the time required to obtain consolidation. One of these methods is to test the ability of exogenous BMPs to increase bone regeneration and accelerate bone consolidation.
骨牵引成骨术（DO）是矫形外科中广泛用于治疗各种病理情况的一种外科技术，例如肢体长度差异、骨畸形或骨缺损。牵张成骨技术的基本原理包括在逐渐牵开两个骨段之前进行横断骨切开。在两段之间的间隙中会产生新的骨组织。人们认为，在 DO 过程中，骨再生是对愈合过程中骨痂受到的纵向机械应变的反应。该技术的一个局限性是新形成的骨组织矿化和巩固所需的时间较长。多项研究表明，在生长因子中，骨形态发生蛋白（BMPs）可能在导致 DO 过程中骨再生和重塑的分子信号级联中起核心作用。目前的研究旨在开发加速骨整合的方法，以减少获得整合所需的时间。其中一种方法是测试外源性 BMP 增加骨再生和加速骨整合的能力。
