Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA.
Proteomics Clin Appl. 2011 Jun;5(5-6):241-7. doi: 10.1002/prca.201000096. Epub 2011 Apr 27.
Despite over 30,000 publications on proteomics in the last decade, and the accumulation of extensive interesting information on the human proteome in diverse observations, the clinical translation of proteomics to-date has had major setbacks. I review here a roadmap for improving the success rate of clinical proteomics. The roadmap includes steps for improvements that need to be made in analytical tools, discovery, validation, clinical application, and post-clinical application appraisal. It is likely that most if not all of the components that are necessary for clinical success are either readily available, or should be possible to put in place with more rigorous research standards and concerted efforts of the research community, clinicians, and health agencies. Enthusiasm for the clinical impact of proteomics may need to be tempered currently until robust evidence can be obtained, but some clinical successes should eventually be feasible.
尽管在过去十年中发表了超过 30000 篇关于蛋白质组学的论文，并且在各种观察中积累了大量关于人类蛋白质组的有趣信息，但蛋白质组学在临床上的转化迄今为止遇到了重大挫折。在这里，我回顾了改善临床蛋白质组学成功率的路线图。该路线图包括需要在分析工具、发现、验证、临床应用和临床后应用评估方面进行改进的步骤。很可能，即使不是全部，对于临床成功所必需的大多数组件要么已经可用，要么应该可以通过更严格的研究标准和研究界、临床医生和卫生机构的协同努力来实现。目前，在获得可靠证据之前，可能需要对蛋白质组学的临床影响保持热情，但最终应该可以实现一些临床成功。
