Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Proteomics Clin Appl. 2011 Jun;5(5-6):222-32. doi: 10.1002/prca.201000125. Epub 2011 Apr 27.
Cardiovascular disease (CVD) is the major cause of mortality and morbidity worldwide. Diagnosis of CVD and risk stratification of patients with CVD remains challenging despite the availability of a wealth of non-invasive and invasive tests. Clinical proteomics analyses a large number of peptides and proteins in biofluids. For clinical applications, the urinary proteome appears particularly attractive due to the relative low complexity compared with the plasma proteome and the noninvasive collection of urine. In this article, we review the results from pilot studies into urinary proteomics of coronary artery disease and discuss the potential of urinary proteomics in the context of pathogenesis of CVD.
心血管疾病（CVD）是全球范围内主要的死亡和发病原因。尽管有大量的非侵入性和侵入性检查，但 CVD 的诊断和风险分层仍然具有挑战性。临床蛋白质组学分析生物流体中的大量肽和蛋白质。对于临床应用，尿液蛋白质组学由于与血浆蛋白质组学相比相对较低的复杂性以及尿液的非侵入性采集，因此特别有吸引力。在本文中，我们回顾了关于冠状动脉疾病尿液蛋白质组学的初步研究结果，并讨论了尿液蛋白质组学在 CVD 发病机制背景下的潜在应用。
