An Manxia, Gao Youhe
Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China; School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China; Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing Key Laboratory of Gene Engineering and Biotechnology, Beijing 100875, China.
Genomics Proteomics Bioinformatics. 2015 Dec;13(6):345-54. doi: 10.1016/j.gpb.2015.08.005. Epub 2016 Jan 2.
Biomarkers are the measurable changes associated with a physiological or pathophysiological process. Unlike blood, urine is not subject to homeostatic mechanisms. Therefore, greater fluctuations could occur in urine than in blood, better reflecting the changes in human body. The roadmap of urine biomarker era was proposed. Although urine analysis has been attempted for clinical diagnosis, and urine has been monitored during the progression of many diseases, particularly urinary system diseases, whether urine can reflect brain disease status remains uncertain. As some biomarkers of brain diseases can be detected in the body fluids such as cerebrospinal fluid and blood, there is a possibility that urine also contain biomarkers of brain diseases. This review summarizes the clues of brain diseases reflected in the urine proteome and metabolome.
生物标志物是与生理或病理生理过程相关的可测量变化。与血液不同,尿液不受体内稳态机制的调节。因此,尿液中的波动可能比血液中的更大,能更好地反映人体的变化。尿液生物标志物时代的路线图已被提出。尽管尿液分析已被尝试用于临床诊断,并且在许多疾病(尤其是泌尿系统疾病)的进展过程中对尿液进行了监测,但尿液是否能反映脑部疾病状态仍不确定。由于在脑脊液和血液等体液中可以检测到一些脑部疾病的生物标志物,尿液中也有可能含有脑部疾病的生物标志物。本综述总结了尿液蛋白质组和代谢组中反映的脑部疾病线索。