Amblard François, Coscoy Sylvie
Centre de recherche de l'Institut Curie et CNRS, UMR168, 26, rue d'Ulm, 75248 Paris, France.
Med Sci (Paris). 2011 Apr;27(4):425-32. doi: 10.1051/medsci/2011274020. Epub 2011 Apr 28.
Dynamics is the essence of life, from the most macroscopic scale of evolution theories or ecology, down to the submicroscopic scale of the molecular mechanisms underlying for instance the activity of enzymes on their chemical target or their mechanical work in our muscles. Thanks to new methods, most phenomena in cell biology must now be reported not only in terms of their biochemistry, but also with a description of their geometric and temporal characteristics using quantitative imaging. This is leading to a dramatic accumulation of data, with little understanding of its deep physiological significance. Based on recent results, we raise here a few questions regarding the possible role of time as a key determinant of the metabolic energy budget, that impacts living cells from the organisation of macromolecular assemblies up to the morphogenesis and stabilisation of tissues.
动力学是生命的本质，从进化理论或生态学的最宏观尺度，到微观尺度，例如酶对其化学靶点的活性或肌肉中的机械作用所基于的分子机制。由于新方法的出现，细胞生物学中的大多数现象现在不仅必须从生物化学角度进行报道，还需要使用定量成像描述其几何和时间特征。这导致了数据的急剧积累，而对其深层生理意义却了解甚少。基于最近的研究结果，我们在此提出几个问题，涉及时间作为代谢能量预算的关键决定因素可能发挥的作用，它从大分子组装的组织一直影响到组织的形态发生和稳定，进而影响活细胞。
