最新技术；健康与疾病中的微生物学。自闭症中的肠道细菌菌群。

State of the art; microbiology in health and disease. Intestinal bacterial flora in autism.

机构信息

Veterans Administration Medical Center, Infectious Diseases Section (111F), Los Angeles, CA 90073, USA.

出版信息

Anaerobe. 2011 Dec;17(6):367-8. doi: 10.1016/j.anaerobe.2011.03.007. Epub 2011 Apr 16.

DOI:10.1016/j.anaerobe.2011.03.007

Abstract

Autism of the regressive variety is selected as an example of the importance of intestinal bacterial microflora in disease other than classical infection. Our studies have indicated that intestinal bacteria play a role in this disease since it responds to oral vancomycin, a drug that is not absorbed from the GI tract. Pyrosequencing studies document an abnormal gut microflora in regressive autism subjects as compared to controls. Finally, we present preliminary evidence suggesting that Desulfovibrio may play a key role in this disease.

摘要

退行性自闭症被选为肠道细菌菌群在非经典感染性疾病中重要性的一个例子。我们的研究表明，肠道细菌在这种疾病中起作用，因为它对口服万古霉素有反应，而万古霉素不会被胃肠道吸收。焦磷酸测序研究记录了退行性自闭症患者的肠道微生物群与对照组相比存在异常。最后，我们提出了初步证据表明脱硫弧菌可能在这种疾病中发挥关键作用。