Rello J, Brunet S, Ausina V, Gurguí M, Canals C, Quintana E, Net A
Servei de Medicina Intensiva, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona.
Enferm Infecc Microbiol Clin. 1990 Aug-Sep;8(7):443-5.
We report a case of disseminated infection produced by Trichosporon beigelii in a woman with acute leukemia and we review the cases described in the literature. In our patient the agent was isolated in the blood and in the bronchoalveolar aspirate. The infection was detected at the time the patient was under granulocytopenia produced by cytostatic therapy with involvement of the bones, kidney, lung, and skin. Although this mycotic agent is commonly sensitive in vitro to amphotericin B, there is not experience enough to recommend it and the mortality is high. Infection by Trichosporon beigelii should be considered in the differential diagnosis of patients with granulocytopenia and infection. This might contribute to improve the prognosis of the disease since and appropriate diagnosis and treatment would be established.
我们报告了1例由白吉利丝孢酵母引起的播散性感染病例,该患者为一名患有急性白血病的女性,同时我们回顾了文献中描述的病例。在我们的患者中,病原体在血液和支气管肺泡灌洗液中被分离出来。该感染在患者接受细胞毒性疗法导致粒细胞减少时被检测到,累及骨骼、肾脏、肺和皮肤。尽管这种真菌病原体在体外通常对两性霉素B敏感,但尚无足够经验推荐使用,且死亡率很高。在粒细胞减少和感染患者的鉴别诊断中应考虑白吉利丝孢酵母感染。这可能有助于改善疾病的预后,因为可以建立适当的诊断和治疗方法。