Hoy J, Hsu K C, Rolston K, Hopfer R L, Luna M, Bodey G P
Rev Infect Dis. 1986 Nov-Dec;8(6):959-67.
During a 10-year period from 1974 to 1984, 19 patients at M. D. Anderson Hospital and Tumor Institute in Houston had invasive infection due to Trichosporon beigelii. Infection was manifested as either a nonspecific febrile illness or pneumonia, and the diagnosis was not suspected before death in 25% of the patients. The majority were neutropenic at the onset of infection, and recovery was directly related to resolution of myelosuppression. The overall mortality rate was 74%. The majority of patients had polymicrobial infections. Twenty-four additional cases reported in the medical literature indicate that this pathogen is an increasingly important cause of mortality in immunosuppressed patients. In both the present series and the cases reported in the literature, the majority of neutropenic patients with disseminated T. beigelii infection died, despite antifungal therapy. Only those patients whose neutropenia resolved following remission of their leukemia recovered.
在1974年至1984年的10年期间，休斯顿的MD安德森医院和肿瘤研究所的19名患者发生了拜氏毛孢子菌侵袭性感染。感染表现为非特异性发热性疾病或肺炎，25%的患者在死亡前未被怀疑患有此病。大多数患者在感染开始时中性粒细胞减少，恢复与骨髓抑制的缓解直接相关。总死亡率为74%。大多数患者发生混合感染。医学文献中报告的另外24例病例表明，这种病原体是免疫抑制患者死亡的一个日益重要的原因。在本系列病例和文献报道的病例中，大多数播散性拜氏毛孢子菌感染的中性粒细胞减少患者尽管接受了抗真菌治疗仍死亡。只有那些白血病缓解后中性粒细胞减少症得到缓解的患者才康复。
