Shabani Amir, Jolfaei Atefeh Ghanbari, Vazmalaei Hajar Ahmadi, Ebrahimi Azizeh Afkham, Naserbakht Morteza
Bipolar Disorders Research Group, Mental Health Research Centre, Iran University of Medical Sciences and Health Services, Tehran, Iran.
J Res Med Sci. 2010 Jan;15(1):20-6.
The existing evidence about the clinical situations of the bipolar patients with opioid dependence is scarce. The present study was carried out to compare the clinical features and course of the bipolar disorder type I regarding the two subgroups of opioid dependent and non-dependent.
There were 178 adult patients with bipolar disorder type I consecutively referred to the Iran Hospital of Psychiatry, Tehran, Iran, from January 2008 to January 2009 who enrolled in the study. The Persian Structured Clinical Interview for DSM-IV axis I disorders (SCID-I), HDRS-17, and Y-MRS were administered for all patients. Other clinical information was gathered through the face-to-face interviews with the probands and the hospital records. The T test, Chi square test and logistic regression were used to analyze the data.
The mean age of probands were 33.6 ± 11.1 years old and they were mostly male. Among the evaluated indices, the factors gender, anxiety disorders comorbidity, non-adherence, and positive family history were different significantly and independently from the other studied factors between opioid dependent and non-dependent bipolar patients.
Despite some differences, the opioid dependent and non-dependent bipolar patients did not have any significant difference regarding most of the examined clinical and course indices.
关于双相情感障碍患者伴有阿片类物质依赖的临床情况，现有证据稀少。本研究旨在比较阿片类物质依赖和非依赖的两个亚组的I型双相情感障碍的临床特征和病程。
2008年1月至2009年1月期间，连续有178名I型双相情感障碍成年患者被转诊至伊朗德黑兰的伊朗精神病医院并纳入研究。对所有患者进行了波斯语版DSM-IV轴I障碍结构化临床访谈（SCID-I）、汉密尔顿抑郁量表17项版（HDRS-17）和杨氏躁狂量表（Y-MRS）评估。其他临床信息通过与先证者的面对面访谈和医院记录收集。采用t检验、卡方检验和逻辑回归分析数据。
先证者的平均年龄为33.6±11.1岁，且大多为男性。在评估指标中，阿片类物质依赖和非依赖的双相情感障碍患者在性别、合并焦虑障碍、不依从和阳性家族史等因素上与其他研究因素存在显著且独立的差异。
尽管存在一些差异，但阿片类物质依赖和非依赖的双相情感障碍患者在大多数检查的临床和病程指标上没有显著差异。
