Haghpanah Sezaneh, Davani Maryam, Samadi Behrang, Ashrafi Afsaneh, Karimi Mehran
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
J Res Med Sci. 2010 May;15(3):150-4.
Beta-thalassemia is considered to be the most frequent hereditary blood disorder worldwide. Lipid abnormalities have been detected in different types of beta-thalassemia. The aim of this study is to assess the lipid profiles in beta-thalassemia major (BTM) and beta-thalassemia intermedia (BTI) patients in southern Iran.
The study group consisted of 55 BTM patients and 50 BTI patients. The control group included 130 sex-and age-matched healthy participants. Serum lipids profiles (total cholesterol, triglycerides, LDL-cholesterol, and HDL-cholesterol) as well as hemoglobin (Hb) and ferritin, were compared between the three groups. P value < 0.05 was considered statistically significant.
There were no significant differences between BTM and BTI patients regarding age or sex. Mean triglyceride concentration was not significantly different between patients and controls. Total cholesterol and LDL-cholesterol were significantly lower in patients with BTM and BTI in comparison with controls (p < 0.001). HDL-cholesterol was significantly lower in patients with BTI than in controls (p < 0.03).
In patients with BTM and BTI, total cholesterol and LDL-cholesterol were lower than in control participants. The mechanisms that may account for these findings are increased erythropoiesis and cholesterol consumption in BTI, and iron overload and oxidative stress in BTM.
β地中海贫血被认为是全球最常见的遗传性血液疾病。在不同类型的β地中海贫血中已检测到脂质异常。本研究的目的是评估伊朗南部重型β地中海贫血（BTM）和中间型β地中海贫血（BTI）患者的血脂谱。
研究组由55例BTM患者和50例BTI患者组成。对照组包括130名年龄和性别匹配的健康参与者。比较三组之间的血清脂质谱（总胆固醇、甘油三酯、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇）以及血红蛋白（Hb）和铁蛋白。P值<0.05被认为具有统计学意义。
BTM和BTI患者在年龄或性别方面无显著差异。患者和对照组之间的平均甘油三酯浓度无显著差异。与对照组相比，BTM和BTI患者的总胆固醇和低密度脂蛋白胆固醇显著降低（p<0.001）。BTI患者的高密度脂蛋白胆固醇显著低于对照组（p<0.03）。
在BTM和BTI患者中，总胆固醇和低密度脂蛋白胆固醇低于对照参与者。可能解释这些发现的机制是BTI中红细胞生成增加和胆固醇消耗，以及BTM中的铁过载和氧化应激。
