Ray Sanghamitra, Saikia Diganta, Vashisht Yachika, Sharma Shikha, Meena Rajesh Kumar, Kumar Manish
Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi, India.
Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi, India.
Hematol Transfus Cell Ther. 2024 Oct-Dec;46(4):345-351. doi: 10.1016/j.htct.2023.02.006. Epub 2023 Apr 22.
This study endeavored to assess the lipid profile and atherogenic lipid indexes in children with transfusion-dependent thalassemia (TDT) and to compare them with matched healthy children.
The study group consisted of a total of 72 TDT patients aged 3 to14 years, while the control group had 83 age- and sex-matched healthy children. The fasting lipid profile and lipid indexes were estimated and the atherogenic index of plasma (AIP), Castelli's risk indexes I and II, atherogenic coefficient were calculated and compared between the two groups.
Compared to the control group, the mean LDL, HDL and cholesterol levels were significantly lower among the case group (p-value < 0.001). The mean VLDL and triglycerides were significantly higher in the case group (p-value < 0.001). Lipid indexes, including the atherogenic index of plasma (AIP), Castelli's risk indexes I and II and atherogenic coefficients were significantly higher in TDT children.
Dyslipidemia and increased risk of atherosclerosis were found in TDT children, as they had elevated atherogenic lipid indexes. Our study underlines the importance of the routine use of these indexes in TDT children. Future studies should focus on lipid indexes in this high-lipid group of children so that preventive strategies can be planned accordingly.
本研究旨在评估依赖输血的地中海贫血（TDT）患儿的血脂谱和致动脉粥样硬化脂质指数，并将其与匹配的健康儿童进行比较。
研究组共有72例3至14岁的TDT患者，对照组有83例年龄和性别匹配的健康儿童。评估空腹血脂谱和脂质指数，并计算两组之间的血浆致动脉粥样硬化指数（AIP）、卡斯泰利风险指数I和II、致动脉粥样硬化系数并进行比较。
与对照组相比，病例组的平均低密度脂蛋白、高密度脂蛋白和胆固醇水平显著较低（p值<0.001）。病例组的平均极低密度脂蛋白和甘油三酯显著较高（p值<0.001）。TDT患儿的脂质指数，包括血浆致动脉粥样硬化指数（AIP）、卡斯泰利风险指数I和II以及致动脉粥样硬化系数显著较高。
TDT患儿存在血脂异常和动脉粥样硬化风险增加，因为他们的致动脉粥样硬化脂质指数升高。我们的研究强调了在TDT患儿中常规使用这些指数的重要性。未来的研究应关注这一高脂儿童群体的脂质指数，以便据此制定预防策略。
