Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, South Korea.
World J Gastroenterol. 2011 Apr 14;17(14):1866-73. doi: 10.3748/wjg.v17.i14.1866.
To investigate the role of glucose transporter 1 (GLUT1) expression in colorectal carcinogenesis and evaluate the correlation with clinicopathological parameters and apoptosis-activating factor-1 (Apaf-1) expression in colorectal adenocarcinomas.
We used tissue microarrays consisting of 26 normal mucosa, 50 adenomas, 515 adenocarcinomas, and 127 metastatic lesions. Medical records were reviewed and clinicopathological analysis was performed.
GLUT1 expression was absent in normal mucosa and low or moderately apparent in 19 cases (38.0%) of 50 adenomas. However, GLUT1 expression was detected in 423 (82.1%) of 515 adenocarcinomas and in 96 (75.6%) of 127 metastatic lesions. GLUT1 expression was significantly correlated with female gender (P = 0.009), non-mucinous tumor type (P = 0.045), poorer differentiation (P = 0.001), lymph node metastasis (P < 0.001), higher AJCC and Dukes stage (P < 0.001 and P < 0.001, respectively). There was a significant inverse correlation between GLUT1 expression and Apaf-1 expression (P = 0.001). In univariate survival analysis, patients with GLUT1 expression demonstrated poor overall survival and disease-free survival (P = 0.047 and P = 0.021, respectively, log-rank test).
GLUT1 expression was frequently increased in adenocarcinomas and metastatic lesions. GLUT1 expression was significantly correlated with poorer clinicopathologic phenotypes and survival of patients with colorectal adenocarcinomas.
研究葡萄糖转运蛋白 1（GLUT1）在结直肠癌变中的作用，并评估其与结直肠腺癌中凋亡激活因子-1（Apaf-1）表达的相关性。
我们使用包含 26 例正常黏膜、50 例腺瘤、515 例腺癌和 127 例转移病灶的组织微阵列。回顾病历并进行临床病理分析。
GLUT1 在正常黏膜中无表达，在 50 例腺瘤中的 19 例（38.0%）中低或中度表达。然而，GLUT1 在 515 例腺癌中的 423 例（82.1%）和 127 例转移病灶中的 96 例（75.6%）中检测到。GLUT1 的表达与女性性别（P = 0.009）、非黏液性肿瘤类型（P = 0.045）、分化较差（P = 0.001）、淋巴结转移（P < 0.001）、更高的 AJCC 和 Dukes 分期（P < 0.001 和 P < 0.001）显著相关。GLUT1 的表达与 Apaf-1 的表达呈显著负相关（P = 0.001）。在单因素生存分析中，GLUT1 表达的患者总生存和无病生存均较差（P = 0.047 和 P = 0.021，log-rank 检验）。
GLUT1 在腺癌和转移病灶中表达频繁增加。GLUT1 的表达与结直肠腺癌患者较差的临床病理表型和生存显著相关。
