感染逆转录病毒载体的人类细胞会获得一种内源性鼠前病毒。
Human cells infected with retrovirus vectors acquire an endogenous murine provirus.
作者信息
Scadden D T, Fuller B, Cunningham J M
机构信息
Howard Hughes Medical Institute, Boston, Massachusetts.
出版信息
J Virol. 1990 Jan;64(1):424-7. doi: 10.1128/JVI.64.1.424-427.1990.
Abstract
A 5.2-kilobase mouse RNA is expressed in human cells following infection with recombinant retroviruses propagated in mouse NIH 3T3 cells as psi-2 pseudotypes. This RNA is transcribed from a defective mink cell focus-forming provirus and copackaged into virions and integrated into human target cell DNA at a frequency comparable to that of the recombinant retrovirus genome.
摘要
一种5.2千碱基的小鼠RNA，在用在小鼠NIH 3T3细胞中作为ψ-2假型繁殖的重组逆转录病毒感染后，在人类细胞中表达。这种RNA是从一种有缺陷的水貂细胞灶形成前病毒转录而来，与重组逆转录病毒基因组以相当的频率共包装进病毒粒子并整合到人类靶细胞DNA中。
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