Endocrinological Ward, Third Provincial Hospital, Rybnik, Poland.
Endokrynol Pol. 2011;62(2):178-80.
Wernicke-Korsakoff syndrome (also called Wernicke's encephalopathy) is a potentially fatal, neuropsychiatric syndrome caused most frequently by thiamine deficiency. The three classic symptoms found together are confusion, ataxia and eyeball manifestations. Memory disturbances can also be symptoms. Wernicke's encephalopathy mainly results from alcohol abuse, but also from malnutrition, cancer, chronic dialysis, thyrotoxicosis and, in well-founded cases, encephalopathy associated with autoimmune thyroid disease (EAATD). The coexistence of many factors makes a proper diagnosis difficult, delays appropriate treatment and consequently reduces the chance of complete recovery. We present the case of a 53 year-old female with Wernicke's encephalopathy caused by chronic malnutrition, surgical operation, as well as thyrotoxicosis. She received treatment with intravenous thiamine administration and also anti-thyroid treatment which caused satisfactory regression of her neurological symptoms.
威尼克-科萨科夫综合征（也称为韦尼克脑病）是一种潜在致命的神经精神综合征，通常由硫胺素缺乏引起。同时出现的三个典型症状是意识混乱、眼球运动障碍和共济失调。记忆障碍也可能是症状之一。韦尼克脑病主要由酗酒引起，但也可能由营养不良、癌症、慢性透析、甲状腺功能亢进症引起，在有充分依据的情况下，还可能由与自身免疫性甲状腺疾病相关的脑病（EAATD）引起。多种因素的共存使得正确诊断变得困难，延迟了适当的治疗，从而降低了完全康复的机会。我们报告了一例由慢性营养不良、手术以及甲状腺功能亢进症引起的 53 岁女性威尼克脑病患者。她接受了静脉注射硫胺素治疗和抗甲状腺治疗，使她的神经系统症状得到了满意的缓解。
