具有内芳基醚和内芳基-芳基键的大环化合物的获取、开发及应用。
Access to macrocycles with an endo aryl ether and an endo aryl-aryl bond, development and application.
作者信息
Wang Qian, Zhu Jieping
机构信息
Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland.
出版信息
Chimia (Aarau). 2011;65(3):168-74. doi: 10.2533/chimia.2011.168.
PMID:21528652
Abstract
Macrocyclization methodologies allowing access to macrocycles having an endo aryl ether and an endo aryl-aryl bond, especially those based on an intramolecular S(N)Ar reaction and the Suzuki-Miyaura reaction, are summarized. Total synthesis of complestatin, a bis-macrocyclic natural product, featuring these two technologies are presented.
摘要
总结了能够合成具有内芳基醚和内芳基-芳基键的大环化合物的大环化方法，特别是基于分子内亲核芳香取代反应和铃木-宫浦反应的方法。还介绍了运用这两种技术对双大环天然产物康普他汀进行的全合成。
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